Glucocorticoid biosynthesis

Glucocorticoid biosynthesis; a very complex multistep process starting from cholesterol in the inner mitochondrial membrane through StAR and StAR-related proteins. Glucocorticoid metabolites are essential in immune system regulation through the glucocorticoid receptor. Most of these compounds are produces in the adrenal gland, however can also be produced in other tissues, e.g. skin, brain, intestine [PMID:32203088]. The pathway knowledge depicted in this model stems from William Griffiths. Metabolic reactions currently without a Rhea ID have been added in bold to the pathway model.

皮质醇生物合成，一种起始于线粒体内膜胆固醇、经StAR及StAR相关蛋白等多步骤的极其复杂的生物合成过程。皮质醇代谢物通过皮质醇受体在免疫系统调节中发挥关键作用。此类化合物大多由肾上腺产生，但亦能在其他组织中合成，例如皮肤、大脑和肠道[PMID:32203088]。本模型中所描绘的代谢途径知识源自威廉·格里菲斯。对于那些目前尚无Rhea ID的代谢反应，已在途径模型中以粗体标注。