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ALDH1A1 regulates the transcription of PD-L1 and targeting ALDH1A1 with disulfiram and PD-L1 with kidney specific nanoparticles delays cyst growth in ADPKD

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP599644
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The elevated ALDH1A1 also functions as a transcription factor or cofactor to increase the expression of Pd-l1 and Ccl2, which regulate PD-L1 mediated immune surveillance and the recruitment of macrophages, respectively. We identify ALDH1A1 targets by CUT-Tag analysis.
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2025-07-11
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