Terms in the Gene Ontology and KEGG pathway databases over-represented among genes that decreased expression with advancing age in the human brain (1,450 genes in total 13,216).

aEASE-score, P-value of a modified Fisher's exact test for overrepresentation [35]. bFold enrichment in each gene group compared to the base set. cGene group with expression that increases with advancing age-at-death (same genes used in Table 4, 1943 genes). dHypergeometric test for underrepresentation using annotated genes from a total set of 13,216 genes as base population [36].