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CRISPR-Cas9 RBM10 synthetic lethality screen
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创建时间：
2023-03-04
相关数据集
Genes identified as congruent to XopE2.
A plus sign marks an SL interaction between a congruent gene and a deletion strain hypersensitive to XopE2.aSL Overlap - the number of SL interactions with hypersensitive deletion strains.bTotal SL -
Figshare2015-12-02 更新50
Results for DESeq2 differential expression analysis for 5 validation RNA-seq experiments of candidate sgRNA against safe-harbor controls.
baseMean: mean of normalized counts across all samples, log2FoldChange: log2 fold-change of candidate sgRNA over safe-harbor sgRNA read counts, lfcSE: standard error estimate of log2 fold-change, pval
Figshare2023-03-16 更新30
Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma. Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma
This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series
NIAID Data Ecosystem10
Systematic synthetic lethal mapping of human cancer genes
We have developed a large CRISPR-based GI map of human cancer to date. Our GI map contains 773,766 pairwise CRISPR-Cas9 genetic perturbations targeting 178 druggable targets (DT) and 67 frequently mut
NIAID Data Ecosystem50
Genomic landscape of BRCA1-deficient tumors upon PARPi treatment. Genomic landscape of BRCA1-deficient tumors upon PARPi treatment
Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is count
NIAID Data Ecosystem10
