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CRISPR-Cas9 RBM10 synthetic lethality screen
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创建时间：
2023-03-04
相关数据集
Mouse Synthetic Lethal Predictions
This is file 1/1 containing all mouse predictions of synthetic lethality using the SINaTRA algorithm. Files are GZipped, tab-delimited text files with the following columns: Gene_ID_1/Gene_ID_2/SINaTR
DataCite Commons2020-09-04 更新80
Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer
Synthetic lethality is a powerful approach for targeting oncogenic drivers in cancer. Recent studies revealed that cancer cells with microsatellite instability (MSI) require Werner (WRN) helicase for
NIAID Data Ecosystem60
ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation
we report a synthetic lethality of ETV6 and EWS-FLI1 in ewing sarcome that is imposed by ETV6 antagonize EWS-FLI1 from particular GGAA microsatellite sites Overall design: RNA-Seq and ChIP-Seq of diff
NIAID Data Ecosystem50
Synthetic lethality by TET-dioxygenase inhibition. Synthetic lethality by TET-dioxygenase inhibition
To characterize target specificity of TETi76, we performed global gene expression analyses of K562TET2+/+ and TET2-/- control cells; TETi76 mimicked expression signatures generated by the loss of TET2
NIAID Data Ecosystem60
DNAseq analysis of a genome-wide loss-of-function CRISPR/Cas9 library established in haploid human embryonic stem cells (hESCs)
The maintenance of pluripotency requires coordinated expression of a set of essential genes. Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide los
NIAID Data Ecosystem50
