OC PK parameters estimated in uninfected and influenza virus-infected ferrets.

a The CL and V parameters are conditioned on oral bioavailability and fraction of parent changed to metabolite.CLd = distribution clearance; CLt = first-order clearance from the central compartment; CV = coefficient of variation; Ka = first-order absorption rate constant; Kt = first-order transfer rate constant for transit compartments; OC = oseltamivir carboxylate; PK = pharmacokinetic; Vc = central compartment volume; Vp = peripheral compartment volume.OC PK parameters estimated in uninfected and influenza virus-infected ferrets.