Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22
收藏Protein Data Bank Japan2024-02-07 更新2026-04-25 收录
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Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22 Descriptor: 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 2 Authors: Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. Deposit date: 2023-10-30 Release date: 2024-01-24 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3.13 Å) Cite: Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
创建时间：
2023-10-30
