Genomic copy-number gain analysis of two MCF7 tamoxifen-resistant cell models. Homo sapiens strain:MCF7

Endocrine resistance is a major obstacle in treating estrogen receptor α (ER)-positive (+) breast cancer. During the process of acquiring endocrine resistance, we hypothesize that genomic aberration may play an important role in contributing to the gene expression related to resistance phenotype. By using two independently developed MCF7 tamoxifen-resistant (TamR) cell models (L and RN), we applied next-generation exome-seq analysis focusing on the copy-number gain in these two TamR cell derivatives.