DNA methylation profiles from a mouse model of Huntington's disease

An Infinium microarray platform (HorvathMammalMethylChip40) was used to generate DNA methylation data from mouse tissues of a heterozygous Huntingtin expansion knock-in (Q175) and wildtype (WT) controls. Mouse tissues: blood, liver, brain cortex, brain cerebellum, and striatum. Mouse strain: C57B/l6J. Two genotypes: Q175 (Htt knockin) and WT control. Mice were sacrificed at age 6 months. Roughly sex balanced (half females). Each sample characteristics value represents: characteristics: Basename = the usual identifier of the methylation array comprised of the SENTRIX ID (i.e. chip identifier) and position (row and column). characteristics: Age = Age at the time of sacrifice. 6 months old mice. characteristics: Sex = F for female mice and M for male mice. characteristics: Genotype = Huntington disease status genotype status: Q175 is the heterozygous knock-in model of Huntington disease. WT denotes wild type controls.