Number of clusters (NOC) at 1.15 Å RMSD cutoff for the MD simulations of wild-type p53 and its functional and nonfunctional mutants.

Cancer mutants are typed in bold letters, rescue mutants are italicized, and non-rescue mutants are underlined. Wild-type p53 is presented as the first line of table. Cancer mutants and their relevant second-site mutants are grouped according to their relevant cancer mutants and sorted in ascending number of clusters in each group. A: active, I: inactive. The thermodynamic stability of G245S_N239Y mutant is given in Ref 36 to be −0.14 kcal/mol.