Supplementary Material for: Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives

Pharmacogenomics (PGx) is increasingly being recognized as a potential tool for improving the efficacy and safety of drug therapy. Therefore, several efforts have been undertaken globally to facilitate the implementation process of PGx into routine clinical practice. Part of these efforts include the formation of PGx working groups working on PGx research, synthesis, and dissemination of PGx data and creation of PGx implementation strategies. In Asia, the Southeast Asian Pharmacogenomics Research Network (SEAPharm) is established to enable and strengthen PGx research among the various PGx communities within but not limited to countries in SEA; with the ultimate goal to support PGx implementation in the region. From the perspective of SEAPharm member countries, there are several key elements essential for PGx implementation at the national level. They include pharmacovigilance database, PGx research, health economics research, dedicated laboratory to support PGx testing for both research and clinical use, structured PGx education, and supportive national health policy. The status of these essential elements is presented here to provide a broad picture of the readiness for PGx implementation among the SEAPharm member countries, and to strengthen the PGx research network and practice in this region.药物基因组学（Pharmacogenomics，以下简称PGx）正日益被视为提升药物治疗疗效与安全性的潜在工具。为此，全球范围内已启动多项工作，以推动PGx落地至常规临床实践的进程。此类工作的重要组成部分包括组建PGx工作组，开展PGx相关研究、数据整合与传播，并制定PGx落地实施策略。在亚洲地区，东南亚药物基因组学研究网络（Southeast Asian Pharmacogenomics Research Network，简称SEAPharm）正式成立，旨在赋能并强化东南亚区域内（不限于东南亚国家）各PGx社群的研究工作，最终目标是支撑该区域的PGx落地实践。从SEAPharm成员国的视角出发，在国家层面推进PGx落地需具备多项核心要素，具体包括药物警戒数据库、PGx研究、卫生经济学研究、可同时支持科研与临床应用的PGx检测专用实验室、系统化PGx教育培训，以及配套的国家卫生政策。本文梳理了上述核心要素的当前现状，旨在全面展现SEAPharm成员国在PGx落地方面的准备就绪程度，并进一步强化本区域的PGx研究网络与实践发展。