Tandem Oxidative α‑Hydroxylation/β-Acetalization Reaction of β‑Ketoamides and Its Applications
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https://figshare.com/articles/dataset/Tandem_Oxidative_Hydroxylation_-Acetalization_Reaction_of_Ketoamides_and_Its_Applications/5584684
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资源简介：
A tandem oxidative α-hydroxylation/β-acetalization
reaction of β-ketoamides was developed in the presence of PIDA
and NaOH. This reaction proceeded
at 25 °C in the absence of a metal catalyst to provide 2-hydroxy-3,3-dimethoxy-N-substituted butanamides in good to excellent yields from
readily available starting materials. The application of this chemistry
to the construction of α-hydroxy-β-ketoamides and quinolinones
was also described.
创建时间：
2017-11-09
