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Discover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride

ChEBI2012-03-15 更新2026-07-21 收录

药物肝毒性

临床前生物标志物发现

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-32891 数据链接链接失效反馈

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Discover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride

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创建时间：

2012-03-15

药物肝毒性

斑马鱼毒理模型

Zebrafish larvae treated with triptolide (5 dpf larvae after exposure to triptolide (1.6μM) for 6 hours) or vehicle control. A total of 16 sequencing experiments were performed (control N=8 and treatm

NIAID Data Ecosystem60

Top 10 active components by degree value.

中药网络药理学

药物肝毒性

ObjectiveTo investigate the pharmacodynamic material basis, multi-target mechanisms of Chelidonii Herba in treating chronic obstructive pulmonary disease (COPD), and its hepatotoxicity pathways using

Figshare2025-09-23 更新50

Gene expression data from primary human hepatocytes treated with GGF2 for 6, 24, or 72 h or 24 h with a 48 h washout.

药物肝毒性

基因表达谱分析

GGF2 is a recombinant human neuregulin-1β in development for chronic heart failure. Phase 1 clinical trials of GGF2 were put on hold when transient elevations in serum aminotransferases and total bili

NIAID Data Ecosystem40

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

药物肝毒性

氧化应激标志物

Effects of Methotrexate (MTX) and Sitagliptin (Sita) on oxidative stress markers in the liver.

NIAID Data Ecosystem60

3'mRNA sequencing of hepatic RNA (MACE) at the time points 24h/48h after acetaminophen (APAP) (300mg/kg) administration

药物肝毒性

RNA测序分析

Hepatic RNA specimens from mice (C57BL/6) of the 4 groups (vehicle-treated at 24h/48h, n=6; acetaminophen (APAP)-treated (300mg/kg) at 24h/48h, n=7) were pooled at equal shares. Thereafter, pooled RNA

NIAID Data Ecosystem40

Discover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride

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