We report that knocking down the Mitochondrial Pruvate Carrier 1 (MPC1) in the hearts of adult mice is sufficient to induce hypertrophy and heart failure. Ventricular mRNA profiles of both WT and MPC
Data from 444 mice of the Collaborative Cross and parental lines. 6 mice per strain for CC lines, 8 mice per strain for parentals, evenly split male/female. 4 mice per strain were treated with the b
The heart is composed of many cell types. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of cell types contained in the heart. Overall design: Cardiomyocyte and non cardiomyoc
Congestive heart failure was done by artificial myocardial infarction. After extracting total RNA from control and infarcted ventricles with Triazol, messenger RNA was isolated with Qiagen mRNA isolat