A bioinformatics approach for integrated transcriptomic and proteomic comparative analyses of model and non-sequenced anopheline vectors of human malaria parasites

PXD ID: PXD000062, experiment: GambiaeOG3, data file: gambiaef11.mzxml. Data published as part of Mol Cell Proteomics. 2012 Oct 17 .From the Abstract: {{i}}... Plasmodium parasites are transmitted by Anopheles mosquitoes and the critical site of interaction is at the mosquito"s luminal midgut brush border. ... To bolster our understanding of P. vivax-An. albimanus midgut interactions, we developed an integrated bioinformatic-hybrid RNASeq-LC-MS/MS approach involving An. albimanus transcriptome (15,764 contigs) and luminal midgut subproteome (9,445 proteins) assembly, which when combined with our custom Diptera protein database (685,078 sequences), facilitated a comparative proteomic analysis of the midgut brush borders of two important malaria vectors, A. gambiae and A. albimanus.{{/i}}