Rhodium-Catalyzed Enantioselective Hydrogenation of Unsaturated Phosphonates by ClickFerrophos Ligands

Newly developed ClickFerrophos II ligands were applied
in the hydrogenation of α,β-unsaturated phosphonates.
The use of a rhodium/ClickFerrophos II catalyst was examined in the
hydrogenation of functionalized α,β-unsaturated phosphonates
and was revealed to be effective for β-alkyl-β-aryl or
β-dialkyl phosphonates, (Z)-β-enolester
phosphonates, and α-phenylethenyl phosphonates, producing the
corresponding chiral phosphonates in good yields with high enantioselectivities
(up to 96% ee).