Characterized proteins involved in sporozoite development and invasion of host cells.

1CCP (members of the LCCL protein family), IMC (inner membrane complex), CS (circumsporozoite), MTIP (myosin A tail domain interacting protein), SSP2 (sporozoite surface protein), TRAP (Thrombospondin related anonymous protein), CRMP (cysteine repeat modular protein), MAEBL (membrane antigen erythrocyte binding like protein ), SPECT (sporozoite microneme protein essential for cell traversal ), CelTOS (cell-traversal protein for ookinetes and sporozoites), PL (phosphoplipase), AMA (apical membrane antigen), SPATR (secreted protein with altered thrombospondin domain), EMP (erythrocyte membrane protein), STARP (sporozoite threonine and asparagine-rich protein), SALSA (sporozoite and liver stage antigen); TRSP (thrombospondin related protein). 2The role of these proteins has been determined by functional analysis in gene-knockout and/or antibody-inhibition studies. 3ASX - asexual blood stages; GCT – gametocytes; GAM – gametes; OOC – oocysts; ODS - oocyst-derived sporozoites; SGS - salivary gland sporozoites.