Serum paraoxonase-1 by directed evolution at pH 6.5 in complex with 2-hydroxyquinoline

NIAID Data Ecosystem2026-05-02 收录

定向进化

小分子-蛋白质结合

数据链接：

https://www.rcsb.org/structure/3SRG 数据链接链接失效反馈

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资源简介：

Serum paraoxonase-1 by directed evolution at pH 6.5 in complex with 2-hydroxyquinoline

创建时间：

2024-10-30

催化元件库的序列数据

定向进化

合成生物学

催化元件库数据集包含了酶催化元件定向挖掘和酶催化元件多目标协同进化数据。通过在土壤中对腈水解酶、腈水合酶等多种酶进行挖掘，将有活性的酶进行基因测序并克隆到表达载体上；通过在数据库对包含腈水解酶、烯烃还原酶、醛酮还原酶、羰基还原酶等在内的多种酶进行筛选，委托生物公司合成酶基因序列，克隆到表达载体上；通过设计的引物对醛酮还原酶、羰基还原酶等在内的多种酶进行定点突变，构建出催化性能增强的酶序列。数据采集

国家基础学科公共科学数据中心130

Thymidine kinase mutants obtained by random sequence selection.

定向进化

抗病毒药物代谢酶工程

Knowledge of the catalytic properties and structural information regarding the amino acid residues that comprise the active site of an enzyme allows one, in principle, to use site-specific mutagenesis

PubMed Central1993-05-01 更新40

Rational Design and Directed Evolution of E. coli Apartate Aminotransferase to Tyrosine Aminotransferase: Mutant P2.

蛋白质工程

定向进化

Rational Design and Directed Evolution of E. coli Apartate Aminotransferase to Tyrosine Aminotransferase: Mutant P2.

NIAID Data Ecosystem10

Replicative RNA enables directed evolution and Darwinian adaptation in mammalian cells

定向进化

哺乳动物细胞

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem50

Benzoylformate decarboxylase F464I and A460V mutant from Pseudomonas putida