Total Synthesis of (−)-Picrinine, (−)-Scholarisine C, and (+)-5-β-Methoxyaspidophylline
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https://figshare.com/articles/dataset/Total_Synthesis_of_-Picrinine_-Scholarisine_C_and_-5-_-Methoxyaspidophylline/15368452
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资源简介：
The
first asymmetric total synthesis of three picrinine-type akuammiline
alkaloids, (−)-picrinine, (−)-scholarisine C, and (+)-5-β-methoxyaspidophylline,
has been accomplished. The synthesis features an efficient acid-promoted
oxo-bridge ring-opening and further carbonyl O-cyclization to assemble
the furoindoline scaffold, an unusual Dauben–Michno oxidation
to construct the requisite α,β-unsaturated aldehyde functionality,
and a nickel-mediated reductive Heck reaction to forge the [3.3.1]-azabicyclic
core.
创建时间：
2021-08-19
