A model for tumor suppression using H-1 parvovirus.
收藏PubMed Central1993-09-15 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC47426/
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资源简介：
A model system is proposed to investigate, at the molecular level, the pathways of tumor suppression. As a tool for the selection of cells with a suppressed phenotype, we used the H-1 parvovirus that preferentially kills various neoplastic cells. From the human K562 leukemia cells, we isolated a clone, KS, that is resistant to the cytopathic effect of the H-1 virus and displays a suppressed malignant phenotype. The suppressed malignancy and the cellular resistance to H-1 killing appear to depend on the activity of wild-type p53. Whereas the KS cells express wild-type p53, the protein is undetectable in the parental K562 cells. Experiments with p53 mutants suggest that wild-type p53, in its functionally intact state, contributes to the resistance against the cytopathic effect of H-1 parvovirus. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-09-15
