Characterization and Correlation of Tissue-Specific Profiles of Transcriptome Activity. Sus scrofa

While kinome analysis has proven valuable in unravelling complex biology and identifying therapeutic targets and biomarkers, considerably less is known about the extent to which kinome data can contribute to a systems biology perspective through integration with data from other omic approaches. To investigate, kinome and transcriptome analyses were performed on four tissues of distinct biological function: liver, spleen, jejunum, and jejunal Peyer’s patches. The objective was to identify tissue-specif expression profiles and correlations between kinome and transcriptome data. Overall design: Six 10 weeks old pigs were sacrificed after ad libitum standard feeding. 4 organs samples were collected (Spleen, Jejunum, Liver, Jejunal Peyer's Patches) from each of 6 pigs, for a total of 24 samples.