Transcriptomic analysis of zebrafish liver reveals effects of ehd3 knockout on fatty acid metabolism

This study aims to investigate the impact of ehd3 gene knockout on liver transcriptome profiles and fatty acid metabolism in zebrafish (Danio rerio). By comparing the transcriptomic differences between ehd3 Homozygous mutants and wild-type controls, we sought to identify differentially expressed genes and pathways involved in lipid synthesis, elongation, and desaturation. The findings will enhance our understanding of the regulatory role of EHD3 in hepatic fatty acid homeostasis and provide insights into the genetic mechanisms underlying lipid metabolism. This research is relevant to both fundamental studies in metabolic biology and potential applications in improving fish nutritional quality and understanding lipid-related disorders.