COPDGene Genetic Analysis

This sub-study phs000COPDGene_Geno contains genotype of subjects available from the phs000study. Summary level phenotypes for the NHLBI COPDGene Cohort study participants can be viewed at the top-level study page phs000179COPDGene_v4 Cohort. Individual level phenotype data and molecular data for all COPDGene Cohort top-level study and sub-study are available by requesting Authorized Access to the NHLBI COPDGene Cohort phs000179study. Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and the only leading cause of death that is steadily increasing in frequency. This project will establish a racially diverse cohort that is sufficiently large and appropriately designed for genome-wide association analysis of COPD. A total of 10,000 subjects will be recruited, including control smokers, definite COPD cases (GOLD Stage 2 to 4), and subjects not included in either group (GOLD 1 or GOLD-Unclassified). This... (for more see dbGaP study page.)