Developmental stage at which expression of the different transgenes induces lethality.

aTen female virgin flies homozygous for the indicated transgene or control w1118 were crossed to seven males homozygous for the Gal4 driver. All crosses were carried out in triplicate at 25°C.bThe crosses were monitored daily and the developmental stage at which lethality occurred was scored.CThe 337-Gal4 was used to drive ubiquitous expression of transgenes.dThe 179-Gal4 driver located on the X-chromosome was used to drive pan-neuronal expression of transgenes. * Neuronal expression of low expressing independent fly line dTip60 HAT mutant (dTip60E431Q A) alone or in conjunction with APP/APP dCT induced lethality in a fraction of the respective F1 progeny at the indicated developmental stage while the remainder of F1 progeny did not exhibit any lethal effect.