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A Highly Regioselective Amination of 6-Aryl-2,4-dichloropyrimidine

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https://figshare.com/articles/dataset/A_Highly_Regioselective_Amination_of_6_Aryl_2_4_dichloropyrimidine/3240298
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A highly regioselective amination of 6-aryl-2,4-dichloropyrimidine with aliphatic secondary amines and aromatic amines has been developed which strongly favors the formation of the C4-substituted product. The reactions with aliphatic amines are carried out using LiHMDS as the base and are catalyzed by Pd, while the aromatic amines require no catalyst.
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2016-05-05
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