PTEN Deficiency Promotes Pathological Vascular Remodeling of Human Coronary Arteries. PTEN Deficiency Promotes Pathological Vascular Remodeling of Human Coronary Arteries

Gene expression profiles of Rat aortic smooth muscle clonal isolates of PTEN knock-down and control wild-type. We used Affymetrix microarrays to detail the global program of gene expression changes between PTEN deficient and wild type smooth muscle cells. We identified distinct classes of up- and down-regulated genes during this process. Overall design: Infection of Rat VSMC's with retroviral shRNA specific to PTEN or non-targeting control in order to compare the gene expression under basal, low serum, conditions.