Supplementary Material for: DAPHNE: A New Tool for the Assessment of the Behavioral Variant of Frontotemporal Dementia

<b><i>Background:</i></b> The diagnosis of behavioral variant of frontotemporal dementia (bvFTD) relies primarily on clinical features and remains challenging. The specificity of the recently revised criteria can be disappointing, justifying development of new clinical tools. <b><i>Objective:</i></b> We produced a behavioral inventory named DAPHNE. This scale (adapted from Rascovsky's criteria) explores six domains: disinhibition, apathy, perseverations, hyperorality, personal neglect and loss of empathy. It is composed of ten items (five answer categories). The aim was (1) to assess the validity and reliability of DAPHNE and (2) to evaluate its contribution in differentiating patients. <b><i>Methods:</i></b> Two scores were computed: DAPHNE-6 (screening) from the six domains and DAPHNE-40 (diagnosis) from the ten items. Reliability and reproducibility were assessed. External validity was studied with the Frontal Behavioral Inventory (FBI) and the Frontotemporal Behavioral Scale (FBS). Finally, the diagnostic performance of DAPHNE was compared to revised criteria, FBI and FBS. <b><i>Results:</i></b> DAPHNE was administered to the caregivers of 89 patients, 36 with bvFTD, 22 with Alzheimer's disease, 15 with progressive supranuclear palsy and 16 with bipolar disorder. Reliability and reproducibility were excellent, as was external validity. DAPHNE-6 allowed bvFTD diagnosis (score ≥4) with a sensitivity of 92%, while DAPHNE-40 (score ≥15) had a specificity of 92%. <b><i>Conclusion:</i></b> We demonstrate excellent psychometric features for DAPHNE. This quick tool could help for both diagnosing and screening bvFTD.**背景：** 额颞叶痴呆行为变异型（behavioral variant of frontotemporal dementia, bvFTD）的诊断主要依赖临床特征，目前仍颇具挑战性。新近修订的诊断标准其特异性未能达到理想水平，故而亟需开发新型临床辅助工具。**目的：** 本研究开发了一款名为DAPHNE的行为评定量表。该量表改编自Rascovsky等提出的诊断标准，涵盖6个维度：脱抑制、淡漠、重复刻板行为、过度口欲症、个人忽视及共情丧失，共包含10个条目，采用5级评分法。本研究的目标有二：一是评估DAPHNE的效度与信度；二是探究其在鉴别不同患者群体中的应用价值。**方法：** 研究设置了两种评分方案：基于6个维度的DAPHNE-6用于筛查，基于10个条目的DAPHNE-40用于诊断。随后对量表的信度与重测信度进行了评估。采用额叶行为量表（Frontal Behavioral Inventory, FBI）与额颞叶行为量表（Frontotemporal Behavioral Scale, FBS）对其外部效度进行验证。最终将DAPHNE的诊断效能与修订版诊断标准、FBI及FBS进行对比分析。**结果：** 本研究共向89例患者的照料者发放了DAPHNE量表，其中36例为bvFTD患者、22例为阿尔茨海默病患者、15例为进行性核上性麻痹患者，另有16例为双相情感障碍患者。结果显示，DAPHNE的信度、重测信度及外部效度均表现优异。当DAPHNE-6的评分临界值设为≥4分时，诊断bvFTD的灵敏度为92%；而DAPHNE-40的评分临界值设为≥15分时，诊断特异度可达92%。**结论：** 本研究证实DAPHNE具备优异的心理测量学特性，这款便捷的评定工具可同时用于bvFTD的筛查与临床诊断。