Aryl hydrocarbon receptor (AhR) is a ligand-activated and cancer releated transcription factor. 2-(1'H-indole-3'-carbonyl)-thiazole-4-carboxylic acid methyl ester (ITE) is an AhR ligand, which regulat

NIAID Data Ecosystem50

RNA-Seq analysis of the impact of a kinase NIK inhibitor (DMBP5) on the human melanoma cell line A375

黑色素瘤靶向治疗

RNA-seq转录组学

Introduction: there is growing evidence that the IFN- -related cytokine signature plays a major role supporting the effect of pharmacological blockade of immune checkpoints. The expression of IFN-

NIAID Data Ecosystem20

Supplementary Dataset S3 from Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition

黑色素瘤靶向治疗

激酶抑制剂敏感性

Supplementary Dataset S3

NIAID Data Ecosystem50

LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

黑色素瘤靶向治疗

LKB1-SIK2信号通路

Metastatic uveal melanomas are highly resistant to all existing treatments. To address this critical issue, we performed a genome-wide CRISPR-Cas9 knockout screen, which revealed the LKB1-SIK2 module

NIAID Data Ecosystem20

Cx43 Enhances Response to BRAF/MEK Inhibitors by Reducing DNA Repair Capacity

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