FRS2 binds to active TrkA receptor

FRS2 binds to TRKA through the same motif (NPXY) around the TRKA phospho-tyrosine residue Y496 to which SHC proteins bind. The competition between SHC proteins and FRS2 for binding to NGF-activated TRKA may provide a novel mechanism by which proliferation and differentiation may be regulated in response to neurotrophin stimulation. Tyrosine phosphorylation of FRS2 occurs within 2 min of NGF stimulation.

FRS2通过围绕TRKA磷酸化酪氨酸残基Y496的相同基序（NPXY）与TRKA结合。SHC蛋白与FRS2竞争结合NGF激活的TRKA的过程可能提供了一种新的调节机制，通过该机制，神经生长因子刺激可调节细胞增殖和分化。在NGF刺激后2分钟内即可发生FRS2的酪氨酸磷酸化。