Neurology paper \"Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study\" Table e-1

Our Neurology 2020 paper titled \"Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study\" explores the cascades of  changes of several well-known Alzheimer disease (AD) markers including cerebrow spinal fluid (CSF), imaging (PET-PIB and MRI) and cognitive markers in cognitively normal participants. The baseline marker data of participants is modeled as a piecewise linear function of baseline age allowing one change point, without and with adjustment for covariates.  The change point of a marker incicates the acceleration time of point after which a greater percentage of the participants present preclinical AD compared to before the change point. Cosnistent with previous research, the study confirmed that Abeta42 showed the earliest change-point around 50 years old and cognition had a late change point around 62. The study further found Tau, pTau and MRI hippalcampal volume had their change point closer to cognition. We identified change poin...