Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2‑Pyridyl Sulfone
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/Nucleophilic_Iododifluoromethylation_of_Carbonyl_Compounds_Using_Difluoromethyl_2_Pyridyl_Sulfone/3384898
下载链接
链接失效反馈官方服务：
资源简介：
A new, efficient
method for iododifluoromethylation
of carbonyl compounds utilizing difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is described. This transformation is achieved
by a nucleophilic addition of 2-PySO2CF2H with
carbonyl compounds and a subsequent iodination of sulfinate, which
is generated in situ by a novel zinc-mediated depyridination reaction.
The method employs mild reaction conditions, exhibits excellent functional-group
tolerance, and can be used in the synthesis of various iododifluoromethylated
carbinols.
创建时间：
2016-05-27
