Nucleophilic Iododifluoromethylation of Carbonyl Compounds Using Difluoromethyl 2‑Pyridyl Sulfone
收藏NIAID Data Ecosystem2026-03-09 收录
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资源简介：
A new, efficient method for iododifluoromethylation of carbonyl compounds utilizing difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) is described. This transformation is achieved by a nucleophilic addition of 2-PySO2CF2H with carbonyl compounds and a subsequent iodination of sulfinate, which is generated in situ by a novel zinc-mediated depyridination reaction. The method employs mild reaction conditions, exhibits excellent functional-group tolerance, and can be used in the synthesis of various iododifluoromethylated carbinols.
创建时间：
2016-05-27
