Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

Premature rupture of membranes is the loss of amniotic fluid due to damage to the chorioamniotic membranes surrounding the fetus before labor. Preterm premature rupture of membranes (PPROM, PPROM) is defined as the rupture of membranes before the 37th week of pregnancy and is seen in 3 percent of all pregnancies. It occurs in approximately 0.5 percent (%) of pregnancies <27 weeks, 1 percent (%) of pregnancies between 27 and 34 weeks, and 1 percent (%) of pregnancies between 34 and 37 weeks [1], [2] .
Although the etiopathogenesis of preterm PROM has not been clearly defined, there are different mechanisms that may be related. The integrity of fetal membranes is due to extracellular membrane proteins, including collagens, fibronectin, and laminin. Matrix metalloproteases (MMPs) reduce membrane strength by causing increased collagen degradation [3]. Tissue inhibitors of MMPs (TIMMPs) bind to MMPs and inhibit MMP-associated proteolysis, thus helping to maintain membrane integrity [4]. It has been shown that intraamniotic infection, especially in early pregnancy, may be associated with PPROM.