PRRDB 2.0: a comprehensive database of pattern-recognition receptors and their ligands

PRRDB 2.0: Pattern-Recognition Receptors & Ligands Database

Welcome to the official repository for PRRDB 2.0, a comprehensive and manually curated database of pattern-recognition receptors (PRRs) and their ligands. This resource is designed for researchers working in immunology, innate immunity, host-pathogen interactions, computational biology, and bioinformatics.

Web Server: https://webs.iiitd.edu.in/raghava/prrdb2/

Citation

Kaur, D., Patiyal, S., Sharma, N., Usmani, S. S., & Raghava, G. P. S. (2019).PRRDB 2.0: A comprehensive database of pattern-recognition receptors and their ligands.Database, 2019, baz076.https://doi.org/10.1093/database/baz076

https://github.com/Piyushh1104/PRRDB2.0.git      

About the Database

PRRDB 2.0 is an updated version of the original PRRDB database that maintains detailed information on pattern-recognition receptors (PRRs) and their ligands, including pathogen-associated molecular patterns (PAMPs).

The database compiles experimentally validated information collected from research articles and public biological databases. It provides comprehensive annotations related to receptor classification, ligands, structures, sequences, origin, and immune functions.

The database was manually curated from:

Research articles

Public biological databases

Swiss-Prot

PubChem

Protein Data Bank (PDB)

Key Features

Large Curated Dataset

~2700 total entries

467 unique PRRs

827 unique PAMPs

Data curated from ~600 research articles

~4500 experimentally determined structures linked from PDB