EticaHub Labs computational protein-design dataset — Cardiovascular Disease — run 538dc9ee-4131-4b70-a56a-47bc1ba0d895

Computational dataset / research audit record, not a validated treatment. This individual run contains 3 archived candidates from 1 reported iterations. The pipeline-selected candidate is #2; its internal automated grade is rejected. Proposed research question (not a demonstrated outcome): The user wants me to propose the next research direction for engineering a MOTS-c analog with enhanced mitochondrial targeting and APJ receptor co-activation for treating heart failure with preserved ejection fraction (HFpEF). Evidence and limitations Computational predictions only. No experimental or clinical evidence is supplied. Scores, automated checks and resolved identifiers do not establish binding, novelty, efficacy, safety or medical benefit. The stored "verified" grade is an internal automated check, not peer review or independent scientific validation. Hypothesis, approach and success criteria below are proposed research, not experiments performed. Checkpoint versions, random seeds and complete tool inputs are not established by this archive export; exact rerun reproducibility is not claimed. Automated fail: Homopolymer runs: 9-residue run Automated warn: Low-complexity regions: 21 window(s) of 12 aa below 1.8 bits Automated fail: Tertiary structure: extended rod (Rg 23.4 Å vs 10.6 Å expected), no long-range contacts Internal publication gate: verification grade is rejected Internal publication gate: target extraction not fully checked Internal publication gate: no PubMed citation resolved Internal publication gate: unresolved target symbols: MOTS, APJ, MTS, AAAAA, EAAAK Files: evidence report, original JSON, all candidate sequences, provenance manifest, license and SHA-256 checksums. Available predicted coordinate exports are included and explicitly labelled; missing structures are not reconstructed. AI-assisted research generated by the EticaHub Labs autopilot. Deaven Mabry is credited as responsible project creator, with EticaHub Labs affiliation. Cited literature remains the work of its original authors; identifier resolution is not claim support.