Gene expression response to infection in self-fertilising fish. Kryptolebias marmoratus

Parasites are strong drivers of evolutionary change and the genetic variation of both host and parasite populations can co-evolve as a function of the parasite's virulence and the host's immune resistance. The role of transcriptome variation in specific interactions between host and parasite genotypes has been less studied and can be confounded by high genotypic variability in natural populations. We have analysed gene expression between two inbred lines of a self-fertilising fish experimentally infected with a parasite under controlled conditions, in order to estimate the role of the genotype in the transcriptome responses to infection using RNA-seq. Overall design: Analysis of gene expression in response to infection in 2 inbred fish lines