Filicinic Acid Based Meroterpenoids with Anti-Epstein–Barr Virus Activities from Hypericum japonicum

Seven filicinic acid–based
meroterpenoids (1–7), possessing
6/6/11, 6/6/7/5, or 6/6/10 ring
systems, were isolated from Hypericum japonicum.
All of them have novel skeletons with the incorporation of sesquiterpenoid
moieties to an acylated filicinic acid. Compounds 2a and 4 exhibited significant efficacy on anti-Epstein–Barr
virus, with EC50 values of 0.57 and 0.49 μM, respectively.
Furthermore, compounds 2a and 4 were well
accommodated to the binding pocket of 2GV9 predicted by the molecular
docking.

从日本金丝桃（Hypericum japonicum）中分离出七种基于菲尼酸（filicinic acid）的杂萜类化合物（1-7号），这些化合物分别具有6/6/11、6/6/7/5或6/6/10的环状结构体系。它们均含有新颖的骨架结构，通过将倍半萜类片段引入酰化的菲尼酸中实现。其中，化合物2a和4在抗Epstein-Barr病毒方面表现出显著活性，其半数抑制浓度（EC50）分别为0.57和0.49微摩尔。此外，化合物2a和4与由分子对接预测的2GV9结合口袋具有良好的适配性。