Our study reports the first genome-wide atlas of functional nodes that mediate proviral silencing in ESCs. It provides evidences for the comprehensive, interconnected and multi-layered genetic/epigen
Averaged sequence tags from biological replicates were normalized to sequencing depth. Output from DEseq2 analysis is included as basemean, log2FC and FDR. Overlap with TRBS, HDAC3 and hyperacetylated
We generated and analyzed ChIP-seq data for H3k4me3, H3k4me1, and H3k27me3. We annotated active and poised promoters and enhancers, as well as regions associated with repressed gene expression and fou
SETDB1 is a key lysine methyltransferase (KMT) required in embryonic stem cells (ESCs), where it silences transposable elements and DNA repeats via histone H3 lysine 9 tri-methylation (H3K9me3), indep
