Histone deacetylase inhibitors in alveolar rhabdomyosarcoma

Multiple histone deacetylase inhibitors were tested on multiple alveolar rhabdomyosarcoma cell lines and multiple patient-derived xenograft models of alveolar rhabdomyosarcoma Overall design: Alveolar rhabdomyosarcoma cell lines were treated with various histone deacetylase inhibitors or with vehicle. Post experiment cells were snap frozen and had RNA isolated from cell pellets. Isolated RNA was sequenced and quantified