Ectoderm differentiation

Model depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lines, following differentiation to multiple lineages (ectoderm, mesoderm, endoderm, embryoid body). The underlying genomic data can be obtained from: https://www.synapse.org/#!Synapse:syn1773109. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2858 CPTAC Assay Portal]

本模型基于文献资料及高度丰富的基因表达谱，通过对比数十个独立的诱导和胚胎多能干细胞系，在分化为多种谱系（外胚层、中胚层、内胚层、胚体）的过程中描绘了外胚层的指定机制。相关基因组数据可通过以下链接获取：https://www.synapse.org/#!Synapse:syn1773109。该通路上的蛋白质具有针对的检测方法，可通过[https://assays.cancer.gov/available_assays?wp_id=WP2858 CPTAC检测门户]获取。