Data for: Genetic variants underlying human bisexual behavior are reproductively advantageous

Because human same-sex sexual behavior (SSB) is heritable and leads to fewer offspring, how SSB-associated alleles have persisted and whether they will remain in human populations are of interest. Using the UK Biobank, we address these questions separately for bisexual behavior (BSB) and exclusive SSB (eSSB) after confirming their genetic distinction. We discover that male BSB is genetically positively correlated with the number of offspring. This unexpected phenomenon is attributable to the horizontal pleiotropy of male risk-taking behavior-associated alleles, because male risk-taking behavior is genetically positively correlated with both BSB and the number of offspring and because genetically controlling male risk-taking behavior abolishes the genetic correlation between male BSB and the number of offspring. By contrast, eSSB is genetically negatively correlated with the number of offspring. Our results suggest that male BSB-associated alleles are likely reproductively advantageous, ..., , , # GWAS summary statistics and codes of the paper \"Genetic variants underlying human bisexual behavior are reproductively advantageous\"

GWAS summary statistics obtained using Regenie for 8 traits: same-sex sexual behavior (SSB), bisexual behavior (Bisexuality), exclusive same-sex sexual behavior (Exclusive_SSB), childlessness (Childless), number of children (N_children), number of children among individuals with at least one child (N_children_nonchildless), number of sexual partners among individuals that only performed opposite-sex sexual behavior (N_Partners_OSB), risk-taking behavior (risk_taking).

genomicSEM.R: the script performs Genomic SEM analysis. To understand the script, see \
Family-based_heritability.ipynb: the script estimates family-based heritability of traits using UKB relative pairs data.