Supplemental tables: Clinical manifestations and healthcare utilization before diagnosis of transthyretin amyloidosis

These are peer-reviewed supplementary materials for the article 'Clinical manifestations and healthcare utilization before diagnosis of transthyretin amyloidosis' published in the Journal of Comparative Effectiveness Research.Supplemental Table I: Diagnostic testing and therapeutic procedures during three years prior to diagnosisSupplemental Table II: Healthcare utilization during three years prior to diagnosisIntroduction: Initial clinical manifestations of transthyretin amyloidosis (ATTR) are not well understood, making timely diagnosis challenging. Methods: Patients aged ≥68 years newly diagnosed with ATTR were identified using Medicare Research Identifiable Files. Symptom manifestation and healthcare utilization were measured during 3 years pre-diagnosis; demographics and comorbidity index during 1-year prediagnosis. Controls (ATTR-free) werematched 1:1 to patientswith ATTR based on age, sex and region; same index date and enrollment as match. Results: We identified 552 matched ATTR-control pairs: mean age 78.3 (standard deviation 6.3) and 64.5% male. Among patients with ATTR (vs controls), cardiovascular conditions (92.9 vs 75.9%) and hospitalization (54.0 vs 35.5%) were frequent during 3 years pre-diagnosis. Conclusion: Patients with ATTR have multiple symptoms and hospitalizations pre-diagnosis, recognition of which may facilitate earlier diagnosis and treatment.

本数据集为发表于《比较疗效研究杂志》的论文《在诊断前转甲状腺蛋白淀粉样变性的临床表现及医疗保健利用》的同行评审补充材料。补充表 I：诊断前三年内的诊断检测和治疗程序；补充表 II：诊断前三年内的医疗保健利用。引言：转甲状腺蛋白淀粉样变性（ATTR）的初始临床表现尚不明确，这使得及时诊断颇具挑战性。研究方法：通过使用医疗保险研究识别文件，确定了年龄≥68岁且新诊断为ATTR的受试者。在诊断前3年内测量症状表现和医疗保健利用情况；在诊断前1年内测量人口统计学和合并症指数。对照组（无ATTR）与ATTR患者按年龄、性别和地区1:1匹配；匹配日期和登记日期与受试者相同。研究结果：我们确定了552对匹配的ATTR-对照组：平均年龄78.3岁（标准差6.3），男性占64.5%。在ATTR患者中（与对照组相比），在诊断前3年内心血管疾病（92.9% vs 75.9%）和住院（54.0% vs 35.5%）较为常见。结论：ATTR患者在诊断前存在多种症状和住院情况，对这些症状的认识可能有助于促进早期诊断和治疗。