Summary of well-characterized compound targets that preferentially regulated production of both IL-17A and IL-17F, or had selectivity for IL-17A or IL-17Fa.

aData from a screen of 144 pharmacologic modulators are summarized to show compound classes and targets that regulated production of both IL-17A and IL-17F or had selectivity for IL-17A or IL-17F in BT co-cultures. The number of agents with selectivity for a specific target is shown in parentheses next to the total number of agents in the screen for that target. Class/targets were only included if greater than 50% of agents specific for a class/target had effects on IL-17A and/or IL-17F. Agents that inhibited both IL-17A and IL-17F, or preferentially inhibited IL-17A or IL-17F had readout values less than log10 ratio −0.2 and were observed at 2 or more non-cytotoxic doses. *Agents against these targets selectively inhibited IL-17A or IL-17F at 2 or more relatively low doses and inhibited both IL-17A and IL-17F at 2 or more higher doses.