Urine chemistry results and comparisons for wild type and HYP mice infused with vehicle or SPR4-peptide.

Mice were sacrificed on day 28 and sera prepared from 16 hour fasted mice housed in metabolic cages. Column headings represent; WT  =  wild type mice, HYP  =  X-linked hypophosphatemic rickets mice, SPR4  =  infused SPR4-peptide and Vehicle  =  Saline infused. Values are means with ± SEM (N = 6). Unpaired t tests with confidence intervals of 95% were used for statistical analysis. Unpaired t tests with confidence intervals of 95% were used for statistical analysis (see also Figure 2). Superscript letters (a, b or c) added to the calculated serum values indicate; a =  significantly different to WT vehicle (WT-VE) infused mice p<0.008, b =  significantly different to HYP vehicle (HYP-VE) infused mice p<0.002 and c =  significantly different to HYP SPR4-peptide (HYP-SPR4) infused mice p<0.02. ND =  Not done. The percentage changes between WT-VE versus WT-SPR4, HYP-VE versus HYP-SPR4 and WT-VE versus HYP-VE are shown in columns 3, 6 and 7 as indicated in the headings. In these columns (3, 6 and 7), the numbers that are significantly different (p<0.01) are denoted by a superscript asterisk (*). Index:FEP(%)  =  Fractional Excretion of Phosphate, Fe Ca (%)  =  Fractional Excretion of Calcium.