GSK3B
收藏rgd.mcw.edu2025-01-21 收录
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资源简介：
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
本基因编码的蛋白质属于糖原合成酶激酶亚家族中的丝氨酸/苏氨酸激酶。该蛋白是葡萄糖稳态的负调节因子，并参与能量代谢、炎症反应、内质网应激、线粒体功能障碍和凋亡途径。该基因的突变与帕金森病和阿尔茨海默病相关联。[由RefSeq提供，2017年8月]
提供机构：
Rat Genome Database
