Crystal structure of PI3Kalpha selective Inhibitor PF-06843195
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Crystal structure of PI3Kalpha selective Inhibitor PF-06843195 Descriptor: 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. Deposit date: 2020-09-21 Release date: 2021-01-06 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.413 Å) Cite: Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
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2020-09-21
