N6-methyladenosine (m6A) RNA methylation is the most abundant internal chemical modifications in eukaryotic messenger RNA (mRNA) as well as long non-coding RNA (lncRNA). Recently, m6A RNA methylation

NIAID Data Ecosystem50

RNAseq analysis of MM13 and MM2 metastatic melanoma PDX cells overexpressing TINCR

肿瘤转录组学

黑色素瘤分子机制

Purpose: Study the changes in cell transcriptome upon overexpression of lncRNA TINCR Methods: Primary melanoma cell line WM902B was transduced with lientiviruses expressing Scrambled and TINCR directe

NIAID Data Ecosystem30

Importance of RAD6B in activation of canonical WNT signaling in melanoma development

黑色素瘤分子机制

Wnt信号通路调控

We have demonstrated that RAD6B, a ubiquitin conjugating enzyme that is a principal component of translesion synthesis pathway, stabilizes and transcriptionally activates beta-catenin by lysine 63-lin

NIAID Data Ecosystem60

Next Generation Sequencing Facilitates Quantitative Analysis of Transcriptomes in negative control and miR-1290 knockdown HCT116 cells

结直肠癌分子机制

MicroRNA功能研究

Colorectal cancer (CRC) ranks third in incidence and second in mortality among cancers worldwide. Emerging researches showed that microRNAs (miRNAs) play an important role in CRC progression. Here, we

NIAID Data Ecosystem30

Additional file 2 of miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK

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