Target genes of thyroid hormone (TH) in brown adipose tissue (BAT) and their role during metabolic stressors [RNA-seq]

To understand the role of TH target genes in BAT, we developped a murine transgenic model in which TH signaling is selectively lost in BAT (BATKO mice). After establishing TH target genes in BAT, we used BATKO mice to understand which pathways were controlled by TH in BAT during metabolic stressors, i.e., cold and high-fat diet (HFD) We performed high-throughput gene expression profiling of BAT in BATKO mice and their control (CTRL) after different stimuli