Signal–to-noise ratio of the FPKM values of TPL-N and EMPTY Y2H-seq screenings.

Genes with SNRTPL-N/EMPTY>6 were retained, listed and ranked from high to low SNR. Flagged genes are italicized. Previously reported interactors of TPL are indicated in bold. Potential interactors that were tested for binary interaction in further validation assays are underlined. A ‘Y’ in bold font indicates the presence of an EAR domain in the wrong frame or in an untranslated region of the gene.