Changes in skeletal muscle PAK1 levels regulate tissue crosstalk to impact whole body glucose homeostasis. Changes in skeletal muscle PAK1 levels regulate tissue crosstalk to impact whole body glucose homeostasis

We have used RNA-seq to identify transcripts expressed in mouse skeletal muscle inducible PAK1 overexpression/knock-out. Overall design: 15 mice preparation examed under 5 condition, WT with doxycyclin, skeletal muscle specific over expressed PAK1 with Doxycyclin or without doxycyclon, and skeletal muscle specific knock out PAK1 with or without doxycyclin.