CD73 contributes to anti-inflammatory properties of afferent lymphatic endothelial cells in humans and mice

The aim of this study is to compare gene expression differences between human lymphatic endothelial cells after they have been treated with siRNA or with different CD73-blocking antibodies. In addition also the gene expression differences after antibody-blocking in human blood endothelial cells are determined. Overall design: Transcriptome profiles from four different donors of human lymphatic and blood endothelial cells after different treatments were generated by NGS using Illumina Hiseq3000.